Which property of tendon scaffolds is essential for controlled delivery of growth factors?

The correct choice emphasizes biofunctional characteristics as essential for controlled delivery of growth factors in tendon scaffolds. Biofunctional characteristics refer to the scaffold’s ability to interact positively with biological systems, which includes the effective retention, release, and modulation of growth factors that promote the healing and regeneration of tendon tissue.

In tissue engineering, scaffolds not only provide a structural framework but also need to actively participate in biological processes. Scaffolds with appropriate biofunctional properties can facilitate the binding of growth factors and their subsequent release in a controlled manner, supporting cell migration, differentiation, and proliferation essential for tendon repair.

While good mechanical integrity is important for load-bearing applications and can influence the mechanical stability of the tissue-engineered construct, it does not directly relate to the effective delivery or bioactivity of growth factors. High porosity can enhance nutrient and oxygen diffusion but might not ensure optimal retention or release dynamics for growth factors. Minimal cellular interaction could impede the biological effectiveness of the scaffold, making it less suitable for delivering growth factors that rely on cellular responses. Therefore, biofunctional characteristics are crucial for achieving the desired outcomes in tendon regeneration and healing.