Which of the following statements is true regarding tissue engineering?

Cellular interactions are indeed critical in scaffold design because they play a vital role in the effectiveness of tissue regeneration. Scaffolds are designed to mimic the natural extracellular matrix, providing not only a physical structure for cells to attach and grow, but also facilitating the biochemical signals necessary for cellular activities such as proliferation, differentiation, and organization. The success of a tissue engineering construct heavily relies on how well the scaffold supports these interactions, influencing tissue development and integration with the host.

In terms of context regarding the other statements: it is not true that all scaffolds are biodegradable; some may be designed for permanent use or have non-biodegradable components. Biomaterials used in tissue engineering can be either synthetic or natural, giving researchers the flexibility to choose based on desired properties. Additionally, while mechanical properties are indeed important for scaffolds, they must also ensure proper cellular interactions, thus indicating that scaffolds require both mechanical and biological considerations in their design.