Which of the following is true about scaffold porosity and pore size?

The choice indicating that a large scaffold pore volume accommodates and delivers a sufficient number of cells is correct. In tissue engineering, scaffolds serve as a supportive structure for cell attachment and growth. A high pore volume within a scaffold is crucial because it allows for the increased environment in which cells can reside. This high porosity facilitates the delivery of cells into the scaffold and provides space for cell proliferation.

Moreover, scaffolds with a significant pore volume enable the effective movement of nutrients, hormones, and waste products necessary for cell survival and function. Adequate pore sizes are essential for supporting these processes, ensuring that cells have access to the biochemical cues they need to thrive. This characteristic is particularly important for creating functional tissue constructs that can mimic natural tissue environments.

The other options, while they may have aspects of truth, do not align as accurately with the principles of tissue engineering regarding scaffold design and function. For example, a large scaffold surface area does not inherently favor cell detachment; rather, it needs to provide sufficient adhesion points for cells. Low porosity would hinder nutrient diffusion and vascularization, rather than facilitate it. Therefore, the focus on pore volume accommodating sufficient cells underscores why this answer stands out in the context of tissue engineering practices.