Which of the following is NOT true regarding scaffold materials?

The statement that the scaffold material should not be absorbable in the body is not true. In tissue engineering, scaffolds serve as temporary structures that support cell attachment, proliferation, and differentiation as new tissue forms. For effective tissue regeneration, it is often advantageous for scaffold materials to be biodegradable. This means that as new tissue develops, the scaffold gradually degrades and is absorbed by the body, thereby reducing the need for surgical removal and allowing for seamless integration of the new tissue with surrounding structures.

Moreover, the degradation rate of the scaffold is critical; it should be controlled to match the rate of tissue formation. This ensures that the scaffold provides adequate support during the initial phases of tissue development and degrades at a pace that supports the growth of the new tissue without leaving behind harmful residues.

The other statements are true. Biocompatibility is essential to prevent adverse immune responses. The ability to facilitate revascularization is also important, as developing tissues require adequate blood supply to deliver nutrients and remove waste products. Therefore, the correct choice reflects a misunderstanding of the role of scaffold materials in tissue engineering.