Which of the following is NOT TRUE about the EQUicycler used in research tasks related to annulus fibrosis tissue engineering?

The statement that is NOT TRUE about the EQUicycler is that it provides means to apply heterogeneous equiaxial strain to tissue constructs while using a gripping apparatus. The EQUicycler is specifically designed to apply uniform or equiaxial mechanical strains to tissue constructs, which is crucial for mimicking the physiological conditions that the annulus fibrosis undergo in vivo.

In tissue engineering, applying equiaxial strain helps maintain the structural integrity and functionality of the engineered tissue by ensuring that all directions of the construct experience the same level of mechanical stress. While the device might utilize a gripping apparatus, its primary function revolves around delivering consistent strain rather than heterogeneous strain, which would involve varying levels of strain across different areas of the construct. Thus, the focus on uniformity is a key feature that underscores its design and application in research related to annulus fibrosis tissue engineering.

In contrast, the other statements are accurate reflections of the EQUicycler's capabilities. It can effectively deliver equiaxial mechanical strain to cell-collagen constructs, support cell viability during extended cultures, and aid in aligning collagen fibers while promoting compaction, all of which are critical to creating an optimal environment for tissue engineering applications.