Which of the following is NOT a side effect of hormone replacement therapy for osteoporosis?

Hormone replacement therapy (HRT) is commonly used to treat conditions such as osteoporosis, particularly in postmenopausal women, by alleviating estrogen deficiency. While there are known side effects associated with HRT, options such as chronic impaired liver function, breast carcinoma, and dementia have established links to the therapy.

Chronic impaired liver function can occur as a result of hormone treatments, particularly with synthetic hormones that may have various metabolic effects. Additionally, the use of hormone therapy, especially estrogen alone or combined with progestin, has shown an increased risk for breast carcinoma, particularly in women who have a history of this disease or other risk factors.

Dementia has also been studied in relation to HRT, with some evidence suggesting that certain hormone therapies may contribute to cognitive decline in older women, particularly those starting therapy after the age of 65.

In contrast, Parkinson's disease has no established association with hormone replacement therapy. Current research does not support the idea that HRT contributes to the development or exacerbation of Parkinson’s disease. Therefore, it is accurate to identify this condition as not being a side effect of HRT for osteoporosis.