Which growth factor is notably associated with increasing granulocyte recruitment?

The growth factor that is notably associated with increasing granulocyte recruitment is PDGF, or Platelet-Derived Growth Factor. PDGF plays a crucial role in the immune response and wound healing processes. It is known to be a potent chemotactic factor for a variety of cells, including granulocytes, which are a type of white blood cell essential for the body's defense against infections.

When tissue injury occurs, PDGF is released into the surrounding area, promoting the influx of granulocytes and other immune cells to the site. This recruitment is important for the initial inflammatory response, where granulocytes help to fight infections and begin the repair process. The ability of PDGF to attract these cells enhances tissue healing and regeneration.

In contrast, the other growth factors listed have different primary roles. bFGF (basic Fibroblast Growth Factor) is primarily involved in angiogenesis and fibroblast proliferation, while VEGF (Vascular Endothelial Growth Factor) is mainly associated with the formation of new blood vessels. GDF-5 and BMP-12 are part of the bone morphogenetic protein family, which are more focused on bone and cartilage development rather than immune cell recruitment. Hence, PDGF’s established role in driving the recruitment of granulocytes makes