Which glycoproteins in the ECM help guide migration?

The correct answer highlights the role of fibronectin in the extracellular matrix (ECM) which is crucial for guiding cell migration. Fibronectin is a high-molecular-weight glycoprotein that plays a significant role in cell adhesion, proliferation, and migration due to its ability to bind to integrins on the cell surface. This interaction facilitates cellular movement through the ECM, helping cells navigate their environment during processes such as wound healing, immune responses, and tissue repair.

The mention of actin in the choice also relates to cell migration, but it is primarily a cytoskeletal protein found within cells, not a component of the ECM that directly influences directional migration. Its role is more supportive in providing the necessary structure for cells to move rather than guiding them through the extracellular environment.

In contrast to the incorrect options, laminin is indeed a critical glycoprotein in the ECM and helps in cell adhesion and migration, but the combination including elastin or tenascin does not directly emphasize the best-known migratory signals. Elastin is primarily involved in providing elasticity to tissues and does not have a significant role in guiding cell migration like fibronectin does. Therefore, while laminin can assist in migration, fibronectin is more specifically known for