Which factor is crucial for the survival of cells in scaffold design?

Pore size is fundamental for the survival of cells in scaffold design because it directly influences several critical aspects of tissue engineering. The size of the pores within a scaffold affects the ability of nutrients, oxygen, and waste products to diffuse throughout the material. Adequate pore size facilitates cellular infiltration, allowing cells to migrate into the scaffold and proliferate, which is essential for the formation of new tissue.

In addition, appropriate pore size is necessary to create a conducive environment for cell attachment and differentiation. If the pores are too small, cells may find it challenging to enter and spread within the scaffold, leading to poor tissue integration and function. Conversely, if the pores are too large, they may not provide sufficient structural support or promote adequate cell-cell interactions.

Other factors such as color, shape, and surface texture can also play roles in the performance of scaffolds but are not as directly linked to the critical physiological processes involved in cell survival. Color does not typically influence cellular behaviors, while shape impacts mechanical properties and how the scaffold integrates with surrounding tissues. Surface texture can aid in cell adhesion but is secondary to the importance of pore size in facilitating nutrient transport and overall cellular viability.