What term refers to changes in cellular function based on substrate-bound adhesion molecules?

The term that refers to changes in cellular function based on substrate-bound adhesion molecules is haptotaxis. This concept involves the directional migration of cells in response to gradients of adhesive proteins or other substrate-bound signals. When cells encounter varying concentrations of these adhesion molecules presented on a surface, they may exhibit different behaviors, such as attachment, spreading, and migration. This process is critical in tissue engineering and regenerative medicine as it influences how cells interact with artificial scaffolds or natural extracellular matrices.

Thigmotaxis refers to movement in response to physical contact with surfaces, while chemotaxis pertains to movement in response to chemical gradients. Galvanotaxis involves movement in response to electric fields. Each of these terms addresses different mechanisms of cellular movement and behavior, but haptotaxis specifically highlights the role of adhesion molecules in guiding cellular responses, making it the most relevant choice in this context.