What is the typical range of pore sizes used for most bone ingrowth settings?

The typical range of pore sizes used for most bone ingrowth settings falls between 150 and 500 μm. This range is critical because it allows for adequate nutrient diffusion and vascularization, which are essential for supporting bone ingrowth and integration into the surrounding tissues. When pore sizes fall within this range, they facilitate the attachment and proliferation of osteoblasts and other cells that are vital for new bone formation.

Pores that are too small may not permit sufficient movement of nutrients and waste products, potentially leading to cell death and ineffective bone regeneration. Conversely, pores that are too large could compromise the mechanical stability of the bone scaffold, potentially leading to failure in structural support. Thus, the 150-500 μm range is optimal, allowing both necessary biological functions and mechanical integrity for successful tissue engineering applications aimed at bone repair and regeneration.