What is a crucial aspect of tissue scaffold design based on the principles of electrospinning?

The importance of pore interconnectivity in tissue scaffold design stems from its critical role in facilitating cellular infiltration, nutrient transport, and waste removal within the scaffold structure. When scaffolds are designed with interconnected pores, they create a three-dimensional network that mimics the natural extracellular matrix. This is essential for tissue regeneration, as it allows for better integration with surrounding tissues and supports the growth and proliferation of cells.

In electrospinning, a technique commonly used for fabricating scaffolds, achieving proper pore interconnectivity can greatly enhance the scaffold's functionality. Scaffolds with well-defined and interconnected pores enable cells to migrate throughout the scaffold, promoting tissue development and overall healing processes. Therefore, the design focus on pore interconnectivity is fundamental to ensure that the scaffold meets the biological and mechanical demands required for effective tissue engineering.

While biocompatibility, tensile strength, and thermal resistance are also important considerations in scaffold design, they do not carry the same level of criticality for promoting cellular interactions and tissue integration as pore interconnectivity does.