What are cell adhesion molecules (CAMs) primarily responsible for?

Cell adhesion molecules (CAMs) are primarily responsible for adhering cells to each other, playing a critical role in maintaining the structure and integrity of tissues. They are essential for the formation of junctions between cells, which allow for effective intercellular connections and communication. By facilitating these connections, CAMs help establish tissue architecture, influence cell movement, and contribute to the overall functionality of tissues.

In the context of tissue engineering, understanding the role of CAMs is crucial, as they can influence cell behavior, such as proliferation, differentiation, and migration, which are important for developing viable tissue constructs. The binding of CAMs on one cell to those on another allows for a stable yet dynamic environment necessary for tissue development and repair.

While cellular communication, strengthening tight junctions, and regulating signaling pathways are important cellular processes that may be influenced by CAMs, their primary function lies in promoting adhesion among cells, which is foundational for all the other processes to occur effectively.