True or False: The ASCs-embedded mechanically stimulated Collagen-PNCOL biphasic scaffold can potentially be utilized to repair the annular defects of the IVD.

The statement is true because adipose-derived stem cells (ASCs) embedded within a mechanically stimulated collagen-polylactic-co-glycolic acid (PNCOL) biphasic scaffold shows promise for repairing annular defects of the intervertebral disc (IVD). The biphasic nature of the scaffold allows for mimicking the natural structure of the IVD, which consists of both a nucleus pulposus and an annulus fibrosus, thus providing a suitable environment for tissue regeneration.

Mechanical stimulation is particularly important as it can enhance the biochemical and mechanical properties of the scaffold, encouraging cell proliferation, matrix synthesis, and overall integration with host tissue. Combining ASCs with this kind of scaffold supports not just cell survival, but also differentiation into appropriate cell types that may contribute to the repair processes needed for the annular defects in the IVD.

This approach harnesses the regenerative potential of stem cells and the supportive properties of a well-designed scaffold, aligning well with current trends in tissue engineering aimed at developing functional solutions for spinal disc repair.