True or False: Scaffolds are porous, degradable structures fabricated from either natural materials or synthetic polymers.

The statement is true. Scaffolds play a crucial role in tissue engineering as they provide a three-dimensional framework that supports cell attachment, growth, and differentiation. The porosity of scaffolds is essential because it enhances nutrient and oxygen diffusion, promoting cell survival and infiltration. Additionally, scaffolds are designed to be degradable, which means they can gradually break down as the tissue regenerates, allowing for the replacement of the scaffold material with natural extracellular matrix components produced by cells over time.

Scaffolds can be made from natural materials, such as collagen, gelatin, chitosan, or alginate, which are biocompatible and can support cell interactions. Alternatively, synthetic polymers, like polylactic acid (PLA) or polycaprolactone (PCL), are used as well, allowing for precise control over the material properties, including degradation rates and mechanical strength.

In summary, the definition provided captures the essential characteristics of scaffolds in tissue engineering, emphasizing their porous nature and degradability, which are vital for supporting tissue regeneration processes.