True or False: Most biodegradable polymers degrade with surface degradation.

The statement that most biodegradable polymers degrade with surface degradation is false. The correct understanding is that many biodegradable polymers undergo bulk degradation instead of just surface degradation.

In bulk degradation, the entire volume of the polymer can be affected by the environmental conditions, leading to a more uniform and often faster breakdown process throughout the material. This process allows the polymer to maintain its structural integrity for a longer duration before it starts to disintegrate, as the degradation is not limited to just the outer surface.

In contrast, surface degradation occurs when the outer layer of a polymer breaks down while the inner matrix remains intact, which can prolong the life of the material before significant degradation occurs. While some biodegradable polymers do indeed follow this mechanism, the majority, particularly those designed for tissue engineering applications, have been engineered to degrade through bulk mechanisms to provide a more predictable and effective release of bioactive agents or the degradation of scaffolds.

Thus, it is accurate to say that most biodegradable polymers primarily exhibit bulk degradation rather than surface degradation, making the statement false.