PDGF is used in tendon tissue engineering because it:

PDGF, or Platelet-Derived Growth Factor, plays a significant role in tissue engineering, particularly in tendon repair and regeneration. Its main function relates to its ability to stimulate various cellular processes beneficial for tissue healing and development.

The correct choice highlights PDGF's influence on tenocytes, which are the cells responsible for maintaining the tendon structure and contributing to the extracellular matrix. PDGF induces these cells to produce and deposit collagen, a critical component of tendon tissue. Collagen not only provides structural integrity but also supports the mechanical properties necessary for tendons to function effectively. By promoting collagen synthesis, PDGF enhances the overall quality and strength of the newly formed tendon tissue.

While PDGF can influence aspects like vascularization and the recruitment of other cells, its specific action in tendon tissue engineering focuses more on the stimulation of tenocytes, aiding in the healing and regeneration process by enhancing collagen production. This is crucial for restoring tendon functionality after injury.