Biomaterials may be designed to not interact or specifically interact with biological systems.

Biomaterials can indeed be engineered to either avoid interaction or to specifically interact with biological systems, making the statement true.

In tissue engineering and regenerative medicine, the design of biomaterials is critical and can be tailored to achieve specific outcomes based on their intended use. Biomaterials that do not interact with biological systems are often used in applications where minimal biological response is desired, such as implants that need to remain inert and not provoke inflammation or immune responses.

Conversely, there are biomaterials designed for specific interactions, such as those that promote cell adhesion, proliferation, or differentiation. These are often functionalized with bioactive molecules or designed in ways that mimic the natural extracellular matrix, fostering a positive and controlled interaction with surrounding tissues.

Thus, the ability to manipulate these interactions plays a pivotal role in developing effective tissue engineering solutions, validating the truth of the statement.